Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physical targets and pharmacology from curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin ‘s the biggest element of the reddish color off turmeric, a keen Indian spruce that is obtained from the rhizome of warm plant Curcuma longa, hence belongs to the Zingiberaceae family. Within section, we talk about the pharmacological facts out of curcumin and mention new molecular basics for these factors. I after that review the latest demonstrated and potential logical spends off curcumin. Curcumin is known historically given that a curative representative, but the apparatus of step is detailed. The newest kissbrides.com titta pГҐ denna webbplats pharmacological outcomes of curcumin seem to be caused by an effective synergism out-of companies off weak biochemical relations which have multiple physiological aim in the interconnected signaling paths. Such goals were enzymes such as for example cyclooxygenase, lipoxygenase and you will necessary protein kinases, and you may transcription products like NF-?B, STAT and you may Nrf2. Modulation of those particles affects downstream affectors that produce the fresh antiinflammatory, antioxidant, chemopreventive, anticancer, and you may antimicrobial points from curcumin. Such consequences was checked out for the clinical trials regarding curcumin to own pain and you will inflammatory problems, malignant tumors, Alzheimer situation, cardio infection, and you may all forms of diabetes. The fresh new trials used varying doses of curcuminwith more wavelengths and you may period, towards standard conclusion one to large doses out of curcumin on number of g have to get therapeutic outcomes. Read more
Curcumin: Synthesis, Emerging Role into the Soreness Administration and Wellness Effects
Book Chapter Types of plant-derived pharmaceuticals which have end up being the notice from proceeded and great lookup and advancement interest provides, thus far, become somewhat scarce. Shortly after several years, the last 20 years was described as good 100-fold boost in the number of scientific content published a year that is away from significance towards accessibility curcumin when you look at the biomedicine. Find out more
Structure, synthesis and physical circumstances off curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many potential pharmacological effects and may also keeps therapeutic apps a number of condition says, as discussed in detail in the previous section. Yet not, the potential medical effectiveness off curcumin is bound of the the physicochemical attributes off bad water solubility and you will instability, and this end up in low bioavailability. Prodrugs out-of curcumin offer a means to upgrade of your own biopharmaceutical and you can pharmacokinetic services, and could make it exploitation of one’s pharmacological results of curcumin. Within chapter, we first comment the fresh physicochemical and pharmacokinetics of curcumin. I up coming define the design of curcumin prodrugs with increased water solubility and you may enhanced toxins stability which is often converted back to totally free curcumin on bioactivation in the vivo. I stress latest achievements here, which have a concentrate on the construction, synthesis and you may evaluation of prodrugs based on promoieties and additionally proteins, efas, nucleic acids, dicarboxylic acids, and you may polymeric material particularly hyaluronic acid and polyethylene glycol. It part provides the cause for optimization of the physicochemical and biopharmaceutical characteristics and the biological factors off curcumin prodrugs, for the mission having fun with of them curcumin derivatives inside the systematic applications. Find out more